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Research Associate - Oncology

Job ID 187963BR Date posted 08/30/2022
  • Rochester, Minnesota
  • Full Time
  • Oncology
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The Research shield at Mayo Clinic is committed to creating a diverse environment and recognizes that diverse research teams make better decisions, are more equipped to solve complex problems and adapt to change, and produce better outcomes. That diversity is about opening up to unconventional ideas that create better outcomes, while recognizing colleagues' unique contributions. Become part of the legacy that embraces these differences and enables us to provide the best care to patients from all over the world.

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Position description
A Research Associate position is available in the Department of Oncology. Two important innovative techniques that we have developed in our lab over the last several years are the basis for our newly funded R01 entitled, Quantitative Assessment of Pre-metastatic Immune Subversion as a Risk Factor for Melanoma. The first technique allows oncology surgeons to isolate afferent lymph channels (or lymph fluid) draining the tumor site from melanoma patients during lymph node resections. We have previously shown that extracellular vesicles (EV) isolated from lymphatic fluid are responsible, at least in part, for creating an immunosuppressive microenvironment, which allows tumor metastases into the sentinel lymph nodes. The second technique is a platform for multiplex immunoflouresence in which primary tumors, metastases, and lymph nodes can be stained for multiple parameters in a serial fashion. We have spent the last several years developing the numerous markers for staining tissue followed by robust data processing pipeline. Thus, the goal of this research project is to use this technology to gain insight into tumor-derived factors in the EVs which are responsible for immune subversion in the sentinel lymph node and how those factors effect tumor and immune cells in the nodes to determine which patients are at risk for recurrence.

The candidate will benefit by learning state of the art techniques to answer an important clinical question, which will inform patient care in the clinical setting. The candidate will be a valued member of a cross-disciplinary team working on exciting, recently NIH-funded works committed to deciphering mechanisms of pre-metastatic niche formation in lymph nodes of patients with melanoma. This project will afford the candidate the opportunity to be an integral member of a R01-funded grant working alongside established researchers, bioinformaticians, physicians and scientists with results having direct translation into the clinic. The laboratory will support the educational success of the candidate by providing opportunities to spearhead manuscript writing, abstract submissions to national conferences and supporting membership in Mayo Clinic's Research Fellow Association.

The ideal candidate will have experience in cellular immunology and/or molecular biology (i.e. cell culture, mass-spectrometry, flow cytometry, immunohistochemical staining etc.). As a part of this appointment, the candidate will be responsible for processing surgically-extracted clinical specimens, conducting and optimizing cell culture experiments, and overseeing mass spectrometry experiments. In addition to molecular and cellular laboratory bench skills, excellent organizational and database management skills will be required to enable data analysis and scientific writing.

The candidate will be supported as a post-doctoral research fellow through an NIH-funded grant and will be given opportunities to guide the team through this exciting new project under the direction of the Principal Investigator. Through this work, the candidate will be equipped with a suite of immunological tools (both established and highly novel) to successfully accomplish this work. The candidate will be integrated into a highly motivated team strongly supported by dedicated bioinformaticists, established research technologists with over 30 years of experience and an accomplished physician-scientist PI who is committed to the overall success of his team members.

Must have a Ph.D., M.D. or equivalent doctoral degree in a field deemed relevant by the program. Requires at least three years of postdoctoral research experience at Mayo Clinic or elsewhere with evidence of publications and other scientific accomplishments.

Additional qualifications
  • Experience in cellular immunology and/or molecular biology (i.e. cell culture, mass-spectrometry, flow cytometry, immunohistochemical staining etc.).
  • Experience processing surgically-extracted clinical specimens, conducting and optimizing cell culture experiments, and overseeing mass spectrometry experiments.
  • Molecular and cellular laboratory bench skills
  • Excellent organizational and database management skills

Benefits eligible

Full Time

Site description
Mayo Clinic is located in the heart of downtown Rochester, Minnesota, a vibrant, friendly city that provides a highly livable environment for more than 34,000 Mayo staff and students. The city is consistently ranked among the best places to live in the United States because of its affordable cost of living, healthy lifestyle, excellent school systems and exceptionally high quality of life.

Kara Schott

As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.
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*The observation program does not meet clinical hours needed for school.

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*The Department of Nursing is not a participant in this program.

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