Cancer Biology
Why Mayo Clinic

Position description
The Chanan-Khan / Paulus hematology research laboratory at Mayo Clinic in Florida is looking for an ambitious, experienced, and self-motivated junior scientist with an interest in translational research in B-cell cancers for the professional rank of Research Associate. The overarching goal of our laboratory is to decipher the immunology and biology of chronic lymphocytic leukemia (CLL), multiple myeloma (MM) and Waldenstrom macroglobulinemia (WM) in order to develop rational drug and immunotherapeutic treatment strategies for our patients. The Scientist selected to join our lab will lead projects on therapeutic targeting of CD38 in CLL and WM (R01 funded research). The Chanan-Khan / Paulus laboratory Lab is also focused on development of novel Bcl-2 family inhibitors (Industry collaboration funded) and on which the Scientist will also have an opportunity to work and lead. The laboratory uses state of the art immune-assays including CyTOF, multi-dimensional flow cytometry / FACS, immunopeptidomics as well as genomic/proteomic techniques such as single cell sequencing and MSD-ELISA on which the scientist must have demonstrable expertise. To determine the activity of experimental therapeutics, we employ a semi-automated drug screening platform, which can test several cell lines and primary patient samples in a high-throughput manner. In vitro/ex vivo drug activity results and pharmacodynamics are then validated in various mouse models and patient-derived xenograft models.
The laboratory forms a core component of the Malignant Hematology Research Group at Mayo Clinic in Florida, which is led by a collaborative unit of 4 principle investigators (clinicians/scientists) and several support staff. The research objective of this group is to develop novel therapeutics for treatment of patients with malignant B-cell cancers; the science and rationale of which is born out of the Chanan-Khan/Paulus laboratory. Our group has been at the forefront in bringing several new drugs into the clinic, including novel Bcl-2 targeting agents, immunomodulating drugs, bi-specific antibodies, and anti-CD38-based treatments. As such, the Scientist will work to develop, lead, and continue projects in the lab that are at the interface of clinical research and basic science. Additionally, the Scientist will also have access to the 3-site Mayo Clinic network of world-class researchers engaged in malignant hematology research.

The junior scientist selected to join our lab will have an individualized mentorship plan; tailored to his or her personal career and publications goals including regular meetings with Drs. Paulus and Chanan-Khan to guarantee a successful career trajectory. This individual will be expected to write and apply for federal, foundation or internal grants with guidance and mentorship from Drs. Chanan-Khan or Paulus. The scientist will also be expected to teach/mentor post-doctoral fellows as well as graduate students who obtain internships in our lab through highly competitive Mayo Clinic-sponsored educational programs. Through these various activities/resources and grant writing opportunities, it is anticipated that the junior scientist will eventually transition towards an independent position, achieve the rank of Assistant Professor, and make a significant impact in the scientific/medical arena. As both Drs. Chanan-Khan and Paulus are actively engaged in research with both academia and industry partners, this is an ideal position for the nominated Scientist considering potential opportunities in academia or industry.
Candidates with strong background in CLL, MM, lymphoma, leukemia, molecular biology, immunology, design of in vitro/ex vivo co-culture assays, mouse models, and preclinical drug testing are particularly encouraged to apply.

The successful Scientist candidate will have:
  • PhD and minimum of 4 years relevant academic research environment and a minimum 3 years of previous experience with discovery, validation, and development of immunotherapeutic, small molecule inhibitors or vaccines.
  • Deep expertise in molecular/cancer biology, immunology and the mechanisms and pathways that govern their functions.
  • Experience in in vivo animal models is a must.
  • Broad working knowledge of platform technologies to evaluate B and T cell function and/or heterogeneity including but not limited to in vitro stimulation assays, high-dimensional FACS or spectral cytometry for phenotypic or functional analysis, transcriptional assessment, population labeling/tracking or fate-mapping, and/or other single-cell analytics. The Scientist will be expected to perform hands-on bench research approximately 50% of time.
  • Strong analytical, troubleshooting, and decision-making skills.
  • Experience working in highly collaborative research environment.
  • Excellent critical thinking and scientific acumen, with a demonstrated ability to analyze, interpret, and clearly communicate (orally and in writing) complex data and their impact to program and research strategy.
  • A strong team player with a passion for science and helping discover and develop novel therapies for unmet medical needs

Eligible candidates should submit curriculum vitae and names of three references to Dr. Aneel Paulus( Please enter “Postdoc Position” in subject line of e-mail.
Academic faculty profiles for Drs. Chanan-Khan and Paulus below:
Chanan-Khan Faculty Profile
Paulus Faculty Profile

A Research Associate at Mayo Clinic is a temporary transitional role with the primary purpose to allow qualified individuals to work within an established investigator’s program in preparation for an academic and/or independent research career. The ability to perform specialized or complex functions would typically be demonstrated through review of scientific accomplishments, contributions, and peer-reviewed publications averaging at least one per year post-doctoral degree. The Research Associate is expected to provide leadership support and training within an established research program.

The following is required for completeness of application:
  • Current curriculum vitae with bibliography
  • Proof of doctoral degree (copy of diploma or final transcript with English translation, if applicable) or a letter from your university's Registrar office indicating you have fulfilled all doctoral program requirements and are eligible to graduate.
Please also be prepared that you may be asked to provide three letters of recommendation to the hiring PI prior to an interview.
Must have a Ph.D., M.D. or equivalent doctoral degree in a field deemed relevant by the program. Requires at least three years of postdoctoral research experience at Mayo Clinic or elsewhere with evidence of publications and other scientific accomplishments.
Additional qualifications

Benefits eligible
Full Time
Site description
Jacksonville is the largest city in area in the continental United States. A beautiful coastal Florida city that features excellent year-round climate, over 20 miles of beaches and outstanding outdoor recreational, cultural and family-oriented amenities. The “River City by the Sea” has an excellent school system, reasonable cost of living and a thriving business environment. Medical professionals and patients are drawn to Jacksonville by an extraordinary network of high-profile healthcare facilities. Jacksonville continues to grow as more people relocate from all over the U.S. and abroad, to see what the great River City has to offer!
Postdoc & Temporary Research
Career profile
Post Doctoral Research
Job posting number
Amelia Hoffman