The Translational Neuroproteomics Laboratory, directed by Dr. Wilfried Rossoll, is seeking a highly motivated and detail-oriented project associate to join our team in the Department of Neuroscience. Our group investigates how abnormal protein aggregation drives neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease (AD), and related proteinopathies.

Our research combines state-of-the-art mass spectrometry–based proteomics, advanced fluorescence microscopy, and a range of molecular and cellular approaches to define the molecular composition of disease-associated protein aggregates. We focus primarily on TDP-43 and tau, key pathological proteins in ALS, FTD, and AD, while also studying related aggregates such as α-synuclein in Parkinson’s disease and Lewy body dementia. By identifying molecular drivers and modifiers of aggregation, our goal is to uncover new therapeutic targets and develop strategies to slow or prevent disease progression.
Using insights gained from proteomic and mechanistic studies, our team conducts experiments in cellular and animal models to determine how aggregates form, spread, and cause toxicity. These studies directly support our broader mission of developing and validating therapeutic approaches for neurodegenerative proteinopathies.

For more information about our research program, please visit:
https://www.mayo.edu/research/labs/translational-neuroproteomics/overview

Responsibilities
We are looking for an enthusiastic individual with a strong interest in neuroscience and a desire to learn new techniques. The ideal candidate will bring curiosity, attention to detail, and basic laboratory and computer skills. Experience with molecular biology, cell biology, or biochemical methods is advantageous. We offer a supportive, collaborative environment with individualized training, mentorship, and opportunities for career development.

The successful candidate will perform diverse laboratory tasks, including:
•    Immunohistochemistry on cultured cells and tissue sections
•    Mammalian cell culture
•    Fluorescence microscopy
•    Protein affinity purification and biochemical assays
•    Sample preparation for mass spectrometry
•    General laboratory support, record-keeping, and data organization

The position is considered non-exempt (hourly), and therefore, all hours worked must be recorded. A Special Project Associate at Mayo Clinic is a temporary position intended to execute experimental studies in support of lab goals and grant commitments as designated by the Principal Investigator. Performs basic statistical data analysis; prepares tables, charts/graphs and assists in organizing data; completes assorted laboratory procedures and assays. Proof of English proficiency is required for J-1 Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic.

The following is required for completeness of application: Current curriculum vitae with bibliography, Proof of highest degree received (if awarded a Bachelor's or Master's degree). Please also be prepared that you may be asked to provide two letters of recommendation to the hiring PI prior to an interview.

• B.S. in Biology, Neuroscience, Biochemistry, or a related field
• For J-1 visa sponsorship, a Master’s degree is required
• Prior experience in molecular biology, cell biology, or biochemistry is an advantage 
• Must have a solid understanding of lab techniques, equipment, and safety.