Mayo Clinic is seeking Histology Technicians and Histotechnologists (HT/HTL) to join a dynamic and collaborative team within Anatomic Pathology. Opportunities are available across multiple specialized laboratory areas, including:

• Histology
• Frozen Section/Surgical Pathology
• Immunohistochemistry (IHC)
• Renal Pathology

Each lab is offering unique workflows, techniques, and clinical impact. 

The Anatomic Pathology Laboratories at Mayo Clinic process a high volume of complex specimens, including hundreds of thousands of paraffin-embedded blocks and over one million slides annually. Specimens include surgical, autopsy, and research material. Our laboratories take pride in contributing to accurate patient diagnoses and advancing scientific knowledge through collaboration with pathologists, clinicians, and research investigators.

Visit the Clinical Labs career site to watch a brief video of Dane discussing a life-changing career in Histology at Mayo Clinic. 

As an HT/HTL, you will play a critical role in preparing high-quality slides for pathologist review. Responsibilities may include embedding, microtomy, cryotomy, special staining, immunohistochemical techniques, and handling of fresh and complex specimens. The work requires attention to detail, adaptability, and a commitment to quality and patient care.

In addition, you will:

• Support training and onboarding of students and new employees
• Collaborate across multidisciplinary teams to ensure timely and accurate results
• Contribute to a respectful, inclusive, and team-oriented work environment
• Adapt to the unique demands and workflows of different subspecialty laboratories

Mayo Clinic offers extensive opportunities for professional growth and career advancement within Anatomic Pathology. Whether you are interested in developing technical expertise across multiple lab areas or specializing in a particular discipline, this role provides a strong foundation for long-term career development.

Don’t miss the opportunity to be part of a team dedicated to excellence in patient care, innovation, and laboratory medicine.

Histology Technician / Histotechnologist (HT/HTL)

As a Histology Technician or Histotechnologist, you will perform a variety of technical procedures to prepare high-quality microscopic slide preparations used by pathologists for diagnostic and prognostic evaluation.

These procedures may include:

• Specimen accessioning and identification
• Specimen processing and embedding
• Microtomy techniques, including: 
  • Paraffin
  • Frozen (cryotomy)
  • Plastic sections
• Routine Hematoxylin and Eosin (H&E) staining
• Special stains
• Immunofluorescence
• Immunohistochemical (IHC) staining
• In situ hybridization

*Individuals hired to this position are required to complete 2 years in this position before becoming eligible to apply to other positions within Mayo Clinic.

**These positions are ineligible for visa sponsorship. Also, Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program**

Histology Technician (HT): 

• Associate degree required.
• Coursework including 24 semester hours of the following: 
  • A minimum of 12 credit hours in chemistry, biology, or medical laboratory technology
  • 6 credit hours in chemistry
  • 6 credit hours in biology
• Histology Technician (HT) certified by the American Society of Clinical Pathologists (ASCP) required by start date

Histotechnologist (HTL):

• Bachelor’s degree required.
• Histotechnologist (HTL) certified by the American Society of Clinical Pathologists (ASCP) required by start date

Additional Qualifications

• Graduate of a NAACLS accredited program preferred. 
• Graduates of the Mayo Clinic School of Health Sciences Histology Technician Program will receive preference.
• Ability to accommodate scheduling adjustments, off shifts, holidays, on-call, and weekend work assignments.

*Employees obtaining certification(s) after January 1, 2004, will be required to demonstrate evidence of ongoing maintenance of certification.

Application Requirements

*All must be included for your application to be considered: 

• CV/Resume
• Cover letter
• Transcripts (unofficial copy accepted) or NACES detailed international equivalency for foreign degrees.  
• Internal candidates must provide their past three performance appraisals. 

**DLMP employees that have been in current lab/position for less than 2 years must attach early release approval from supervisor. 

***Non-DLMP internal applicants that have been in their current department/position for less than 1 year must attach early release approval from supervisor. 

*International transcript:

• MUST have a DETAILED equivalency evaluation.
• MUST show US equivalent degree.
• Evaluation MUST be completed from an organization listed as a member of the National Association of Credential Evaluation Services (NACES) www.naces.org OR the Association of International Credential Evaluators, Inc. (AICE) www.aice-eval.org