Research Fellow - Structural Biology (cryo-EM)
Job ID 185309BR Date posted 04/01/2023- Rochester, MN
- Full Time
- Biochemistry & Molecular Biology
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Responsibilities
A postdoctoral position is available in the department of Biochemistry and Molecular Biology at Mayo Clinic with Dr. Georges Mer. The focus will be on the structural and functional characterization of multi-subunit molecular assemblies involved in the maintenance of genomic and epigenomic stability using integrative approaches.We are specifically seeking a recent Ph.D. graduate who has expertise in cryo-electron microscopy (cryo-EM) sample preparation, optimization and data processing. The candidate will have ample access to new state-of-art instrumentation on site at Mayo Clinic Rochester for single-particle cryo-EM, but also for X-ray crystallography and NMR spectroscopy.Additional required qualifications:Excellent communication skills with the ability to work independently and as part of a teamDemonstrated skills in scientific writing as evidenced from peer-reviewed publicationsAbility to perform and prioritize multiple tasks while maintaining meticulous experimental records and documentationSelected recent studies from our team:Hu Q et al. Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation. Nature 2021; 596(7872):438-443. https://www.nature.com/articles/s41586-021-03716-8Wang et al. ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication. Sci Adv 2021; 7(25):eabd9208. https://pubmed.ncbi.nlm.nih.gov/34144977/Botuyan MV et al. Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein. Nat Struct Mol Biol 2018; 25(7):591-600. https://www.ncbi.nlm.nih.gov/pubmed/29967538Hu Q et al. Mechanisms of ubiquitin-nucleosome recognition and regulation of 53BP1 chromatin recruitment by RNF168/169 and RAD18. Mol Cell 2017; 66(4):473-487. https://pubmed.ncbi.nlm.nih.gov/28506460/ Dran?? P et al. TIRR regulates 53BP1 by masking its histone methyl-lysine binding function. Nature 2017; 543(7644):211-216. https://pubmed.ncbi.nlm.nih.gov/28241136/
Qualifications
Must have a Ph.D., M.D., or equivalent doctoral degree in a field deemed relevant by the program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at Mayo Clinic or elsewhere.
Exemption Status
Exempt
Compensation Detail
Education, experience and tenure may be considered along with internal equity when job offers are extended.
Benefits Eligible
Yes
Schedule
Full Time
Hours/Pay Period
80
International Assignment
No
Site Description
As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.
Recruiter
Beza Dejene
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