We are seeking a motivated postdoctoral Research Fellow to join us - Mayo Clinic's Center for Individualized Medicine Translational Omics Program (TOP). We are an innovative and driven team of investigators focused on the interpretation of -omic data for diagnostic, translational, and preventive applications. Our research involves innovating, implementing, and translating diagnostic and therapeutic methods to address rare and/or undiagnosed genetic diseases and population genomic sequencing. Mayo Clinic's Center for Individualized Medicine was established to advance genomic sequencing into clinical practice and transform the way we care for patients. We work in close collaboration with many healthcare professionals, including molecular and medical geneticists, and experts in rare diseases and preventive medicine to create solutions that will impact the future of patient care.

This team actively develops cutting-edge methods for interpreting genetic variants in the context of inherited disease. We are embedded in a multidisciplinary environment striving to find answers for our patients. These positions require talented individuals grounded in the fundamentals of genomic variant interpretation and trained in informatics or data science, capable of leading efforts to innovate our genomic focused interpretation platform. If you are passionate about genetics, capable of thinking outside the box, creative in your ability to solve the mysteries you are faced with, and able to interact in an energetic and driven collaborative team science environment, we invite you to apply for this research fellow position.

Responsibilities are as follows:
     •   Use experience in -omic data analysis, bioinformatics, and data science to design the next generation of genomic data interpretation tools facilitating rapid and automated variant classification and data reannotation
     •   Fundamentally understand the current best-practice principals guiding genetic variant interpretation in the context of rare and undiagnosed disease, as well as preventive (i.e. 'healthy screen') testing
     •   Propose and facilitate research efforts to functionally characterize variants or genes of uncertain significance to determine pathogenicity
     •   Propose and facilitate research efforts to evaluate new methods arounds structured phenotype extraction, literature mining, and data integration
in support of assessing variants or genes of uncertain significance to determine pathogenicity
     •   Communicate effectively with internal and external clinicians, researchers, and laboratorians
     •   Establish and manage internal and external collaborations
     •   Contribute to the development and improvement of analytical workflows for -omic data types and data integration
     •   Present genetic findings and variant interpretation regularly to internal and external groups
     •   Routinely write and publish scientific research, case reports, and methods papers

A Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator.
Qualified individuals will demonstrate the potential for research as evidenced by their
training and peer-reviewed publications and should become competitive for national research grants. Proof of English proficiency is required for J-1
Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic.

Qualifications
The following is required for completeness of application:
     •   Current curriculum vitae with bibliography
     •   Proof of MD, PhD, or MD/PhD degree (copy of diploma or final transcript with English translation, if applicable) or a letter from your university's Registrar office indicating you have fulfilled all doctoral program requirements and are eligible to graduate.

Please also be prepared that you may be asked to provide three letters of recommendation to the hiring PI prior to an interview.

Must have a Ph.D., M.D., or equivalent doctoral degree in a field deemed relevant by the program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at Mayo Clinic or elsewhere.