Research Fellow - Mitochondrial Biology

Why Mayo Clinic
The Research shield at Mayo Clinic is committed to creating a diverse environment and recognizes that diverse research teams make better decisions, are more equipped to solve complex problems and adapt to change, and produce better outcomes. That diversity is about opening up to unconventional ideas that create better outcomes, while recognizing colleagues' unique contributions. Become part of the legacy that embraces these differences and enables us to provide the best care to patients from all over the world.
Position description
A post-doctoral position is available immediately in the Department of Neurology at the Mayo Clinic College of Medicine. This one-year renewable position will be focused on studies of the effect of small molecules partial mitochondrial complex I inhibitors on cellular energetics in multiple models of neurodegenerative diseases and chronological aging. The laboratory integrates several disciplines, including mitochondria biology, biochemistry, systems biology approaches (metabolomic, transcriptomic, proteomic), and has a strong translational focus, with activities in preclinical studies and development of novel therapeutics and biomarkers of efficacy. We are seeking a highly motivated individual with a solid background in mitochondria function and cellular energetics. The successful candidate will be a self-driven scientist, enjoying challenging research projects in a supportive multidisciplinary environment, and working in a timely fashion with team members. Enjoyment of team science is essential, along with strong communication and presentation skills in English. Investigation will be conducted in primary neurons, cultured cells including human neurons, and mitochondria isolated from various mouse tissues, and synaptosomes from mouse brain. The in-depth knowledge of techniques involving the interrogation of mitochondrial function including the Seahorse Analyzer, cellular energetics and metabolism is essential.

Required Qualifications:
  • Candidates must have a Ph.D. or M.D. /Ph.D. degree in Biological Sciences and have at least two-year research experiences in the neuroscience and/or cellular energetics field.
  • Proficiency in techniques involving mitochondrial function including the Seahorse Analyzer, cellular energetics and metabolism is essential.
  • Basic cell biology techniques including ELISA, SDS-PAGE, western blot, PCR, and other basic assays.
  • Experience with cell culture techniques.
  • The ability to work with animals

The candidate will also be expected to write manuscripts reporting research findings, originate new, related, or follow-up research projects, and to originate/participate in grant proposal writing to support the lab. This opportunity is open to U.S. and non-U.S. residents; position is available immediately.

A Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Proof of English proficiency is required for J-1 Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic.

The following is required for completeness of application:
  • Current curriculum vitae with bibliography
  • Proof of doctoral degree (copy of diploma or final transcript with English translation, if applicable) or a letter from your university's Registrar office indicating you have fulfilled all doctoral program requirements and are eligible to graduate.
Applications, including curriculum vitae and bibliography, summary of past accomplishments, and three letters of recommendation, should be submitted together.

To learn more about Dr. Trushina's research, please visit her faculty profile here:

Eugenia Trushina, PhD
Mayo Clinic
200 First Street SW Rochester, MN U.S.A. 55905
Must have a Ph.D., M.D., or equivalent doctoral degree in a field deemed relevant by the program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at Mayo Clinic or elsewhere.
Benefits eligible
Full Time
Site description
Mayo Clinic is located in the heart of downtown Rochester, Minnesota, a vibrant, friendly city that provides a highly livable environment for more than 34,000 Mayo staff and students. The city is consistently ranked among the best places to live in the United States because of its affordable cost of living, healthy lifestyle, excellent school systems and exceptionally high quality of life.
Postdoc & Temporary Research
Career profile
Post Doctoral Research
Job posting number
Stephanie Fredrickson
Equal opportunity employer
As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.